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Description

Cefoperazone, ceftazidime, and ceftriaxone are third-generation cephalosporins commonly used in clinical practice. They are all semi-synthetic broad-spectrum β-lactam antibacterial drugs. , thus hindering the formation of cell walls, leading to the death of bacteria and exerting an antibacterial effect. The third-generation cephalosporins have a stronger effect on Gram-negative bacilli than the first and second generations, and are weaker than the first and second generations on Gram-positive bacteria. They have no nephrotoxicity, and their enzyme stability is stronger than that of the first and second generations. Bacteria and anaerobic bacteria have different degrees of antibacterial effect.Silikonpuppen There are many similarities between the antimicrobial spectrum and indications, so what are the differences between the three specific drugs? How to choose clinically?
1. The difference in antibacterial activity
Ceftazidime is the drug with the strongest effect on Pseudomonas aeruginosa and Serratia among cephalosporins; cefoperazone is unstable to β-lactamase, and it is often used in combination with enzyme inhibitors; ceftriaxone is a cephalosporin The drug with the longest half-life in the class. Ceftazidime and cefoperazone have strong antibacterial activity against Gram-negative bacilli, including Pseudomonas aeruginosa,SE DOLL but are relatively weak against Gram-positive bacteria. Ceftriaxone has strong antibacterial activity against Streptococcus, especially Streptococcus pneumoniae, but is ineffective against Pseudomonas aeruginosa.
2. The difference in pharmacokinetics
Foperazone and ceftriaxone are mainly metabolized by bile and kidney, so patients with renal insufficiency do not need to adjust the dose[2], Lebensechte Sexpuppen and these two drugs are the first choice for biliary tract infection; ceftazidime is mainly metabolized by the kidney, so patients with renal insufficiency need to reduce Dosage application[2], ceftazidime is the first choice of the three drugs for urinary tract infection.
3. Differences in clinical drug selection
All three drugs belong to class B and are relatively safe to use during pregnancy.Kleine Brüste Sexpuppe Ceftriaxone and ceftazidime have a lactation classification of L1 (safest), and cefoperazone has a lactation classification of L2 (relatively safe).
4. The difference between adverse reactions and precautions
The adverse reactions of the three cephalosporins are similar, common allergic reactions such as rash, itching, drug fever, diarrhea, nausea, vomiting and other digestive system symptoms. Third-generation cephalosporins can cause superinfection due to their broad antibacterial spectrum, such as pseudomembranous colitis and candida infection.Anime Sex Doll The "Guiding Principles for Skin Tests of β-Lactam Antibacterial Drugs (2021 Edition)" issued by the National Health Commission pointed out that [6], cephalosporin antibiotics need to be tested in the following two situations: previously clear penicillin or cephalosporin Patients with a history of mycocin (immediate) allergy; skin tests are required as stipulated in the drug instructions. If the drug manufacturer's instructions clearly indicate that "an allergy test is required before using the drug", attention should be paid when using the drug.

Description

Cefoperazone, ceftazidime, and ceftriaxone are third-generation cephalosporins commonly used in clinical practice. They are all semi-synthetic broad-spectrum β-lactam antibacterial drugs. , thus hindering the formation of cell walls, leading to the death of bacteria and exerting an antibacterial effect. The third-generation cephalosporins have a stronger effect on Gram-negative bacilli than the first and second generations, and are weaker than the first and second generations on Gram-positive bacteria. They have no nephrotoxicity, and their enzyme stability is stronger than that of the first and second generations. Bacteria and anaerobic bacteria have different degrees of antibacterial effect.Silikonpuppen There are many similarities between the antimicrobial spectrum and indications, so what are the differences between the three specific drugs? How to choose clinically?
1. The difference in antibacterial activity
Ceftazidime is the drug with the strongest effect on Pseudomonas aeruginosa and Serratia among cephalosporins; cefoperazone is unstable to β-lactamase, and it is often used in combination with enzyme inhibitors; ceftriaxone is a cephalosporin The drug with the longest half-life in the class. Ceftazidime and cefoperazone have strong antibacterial activity against Gram-negative bacilli, including Pseudomonas aeruginosa,SE DOLL but are relatively weak against Gram-positive bacteria. Ceftriaxone has strong antibacterial activity against Streptococcus, especially Streptococcus pneumoniae, but is ineffective against Pseudomonas aeruginosa.
2. The difference in pharmacokinetics
Foperazone and ceftriaxone are mainly metabolized by bile and kidney, so patients with renal insufficiency do not need to adjust the dose[2], Lebensechte Sexpuppen and these two drugs are the first choice for biliary tract infection; ceftazidime is mainly metabolized by the kidney, so patients with renal insufficiency need to reduce Dosage application[2], ceftazidime is the first choice of the three drugs for urinary tract infection.
3. Differences in clinical drug selection
All three drugs belong to class B and are relatively safe to use during pregnancy.Kleine Brüste Sexpuppe Ceftriaxone and ceftazidime have a lactation classification of L1 (safest), and cefoperazone has a lactation classification of L2 (relatively safe).
4. The difference between adverse reactions and precautions
The adverse reactions of the three cephalosporins are similar, common allergic reactions such as rash, itching, drug fever, diarrhea, nausea, vomiting and other digestive system symptoms. Third-generation cephalosporins can cause superinfection due to their broad antibacterial spectrum, such as pseudomembranous colitis and candida infection.Anime Sex Doll The "Guiding Principles for Skin Tests of β-Lactam Antibacterial Drugs (2021 Edition)" issued by the National Health Commission pointed out that [6], cephalosporin antibiotics need to be tested in the following two situations: previously clear penicillin or cephalosporin Patients with a history of mycocin (immediate) allergy; skin tests are required as stipulated in the drug instructions. If the drug manufacturer's instructions clearly indicate that "an allergy test is required before using the drug", attention should be paid when using the drug.