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Matchup 2: Samus Aran (Metroid) vs. Leon Kennedy (Resident Evil)

Both are used to fighting armies by themselves, usually with a firearm, and wherever they go, the same group of villains always seems to follow them to cause more trouble (the space pirates and metroids for Samus and the Umbrella Corp for Leon).

I'm using Leon because I think the Resident Evil 4 cast is better suited for a Nintendo crossover (since, you know, Resident Evil 4 on the Wii is still considered one of the best games in the entire franchise). That and the reps in Marvel vs. Capcom were all from 1-3. Now I'm trying to think of a decent opponent for Ada Wong...

Description
Matchup 2: Samus Aran (Metroid) vs. Leon Kennedy (Resident Evil)

Both are used to fighting armies by themselves, usually with a firearm, and wherever they go, the same group of villains always seems to follow them to cause more trouble (the space pirates and metroids for Samus and the Umbrella Corp for Leon).

I'm using Leon because I think the Resident Evil 4 cast is better suited for a Nintendo crossover (since, you know, Resident Evil 4 on the Wii is still considered one of the best games in the entire franchise). That and the reps in Marvel vs. Capcom were all from 1-3. Now I'm trying to think of a decent opponent for Ada Wong...